From the South
Take 95 North to Maine. Once in Maine, follow 95 North to 295 North. Get off 295 North at Exit 28 (Brunswick). Pick up Route 1 in Brunswick, and follow for about 20 miles to Wiscasset.
From the North
Take 95 South to Augusta, Exit 112. From the Exit, take a left on to 27 East. Follow Route 27 until it intersects with Route 1 in Wiscasset.